NFE2

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.^[5][6]

NFE2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KZ5
Identifiers
Aliases	NFE2, NF-E2, p45, nuclear factor, erythroid 2
External IDs	OMIM: 601490; MGI: 97308; HomoloGene: 4491; GeneCards: NFE2; OMA:NFE2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 54,292,111 bp[1] End 54,301,015 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.62 cM Start 103,156,639 bp[2] End 103,166,830 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte granulocyte trabecular bone bone marrow bone marrow cells spleen testicle right lung upper lobe of left lung Top expressed in granulocyte fetal liver hematopoietic progenitor cell tibiofemoral joint blood spleen human fetus yolk sac embryo bone marrow body of femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding transcription coactivator activity transcription cis-regulatory region binding protein binding WW domain binding DNA-binding transcription factor activity sequence-specific DNA binding DNA binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm PML body nucleus nucleoplasm protein-DNA complex Biological process hemostasis regulation of transcription, DNA-templated blood coagulation blood circulation transcription, DNA-templated multicellular organism development positive regulation of transcription, DNA-templated nucleosome disassembly regulation of transcription by RNA polymerase II regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4778 18022 Ensembl ENSG00000123405 ENSMUSG00000058794 UniProt Q16621 Q07279 RefSeq (mRNA) NM_001136023 NM_001261461 NM_006163 NM_001400365 NM_001400372 NM_001400373 NM_008685 NM_001302338 NM_001302339 NM_001302340 NM_001302341 NM_001302343 NM_001400376 RefSeq (protein) NP_001129495 NP_001248390 NP_006154 NP_001289267 NP_001289268 NP_001289269 NP_001289270 NP_001289272 NP_032711 NP_001387305 Location (UCSC) Chr 12: 54.29 – 54.3 Mb Chr 15: 103.16 – 103.17 Mb PubMed search [3] [4]
Wikidata
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It is involved in megakaryocyte production.^[7]

Interactions

NFE2 has been shown to interact with CREB-binding protein.^[8]