NFIA

For the airport in Niagara Falls, New York, see Niagara Falls International Airport.

Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene.^[5][6]

NFIA
Identifiers
Aliases	NFIA, CTF, NF-I/A, NF1-A, NFI-A, NFI-L, nuclear factor I A, BRMUTD
External IDs	OMIM: 600727; MGI: 108056; HomoloGene: 4086; GeneCards: NFIA; OMA:NFIA - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 60,865,259 bp[1] End 61,462,788 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C5- C6|4 45.52 cM Start 97,660,971 bp[2] End 98,007,111 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus urethra saphenous vein vena cava buccal mucosa cell cardia nipple parietal pleura endothelial cell synovial joint Top expressed in seminal vesicula vestibular membrane of cochlear duct vestibular sensory epithelium external carotid artery Rostral migratory stream internal carotid artery lobe of cerebellum cerebellar vermis atrioventricular valve facial motor nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding chromatin binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cell junction intracellular anatomical structure nucleus nucleoplasm Biological process viral genome replication DNA replication regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated synapse maturation transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II ureter development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4774 18027 Ensembl ENSG00000162599 ENSMUSG00000028565 UniProt Q12857 Q02780 RefSeq (mRNA) NM_001134673 NM_001145511 NM_001145512 NM_005595 NM_001122952 NM_001122953 NM_010905 RefSeq (protein) NP_001128145 NP_001138983 NP_001138984 NP_005586 NP_001116424 NP_001116425 NP_035035 Location (UCSC) Chr 1: 60.87 – 61.46 Mb Chr 4: 97.66 – 98.01 Mb PubMed search [3] [4]
Wikidata
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Function

Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by OMIM]^[6]