NFIL3

Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.^[5]

NFIL3
Identifiers
Aliases	NFIL3, E4BP4, IL3BP1, NF-IL3A, NFIL3A, nuclear factor, interleukin 3 regulated
External IDs	OMIM: 605327; MGI: 109495; HomoloGene: 3928; GeneCards: NFIL3; OMA:NFIL3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.31 Start 91,409,045 bp[1] End 91,423,832 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 27.68 cM Start 53,121,245 bp[2] End 53,135,109 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava pericardium gastric mucosa left uterine tube cartilage tissue popliteal artery tibial arteries stromal cell of endometrium periodontal fiber right ventricle Top expressed in muscle of thigh gastrula granulocyte zygote primary oocyte secondary oocyte digastric muscle left lobe of liver plantaris muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding transcription corepressor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific identical protein binding Cellular component nucleus Biological process cellular response to interleukin-4 positive regulation of gene expression regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II circadian rhythm immune response transcription, DNA-templated rhythmic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4783 18030 Ensembl ENSG00000165030 ENSMUSG00000056749 UniProt Q16649 O08750 RefSeq (mRNA) NM_005384 NM_001289999 NM_001290000 NM_017373 RefSeq (protein) NP_001276928 NP_001276929 NP_005375 NP_059069 Location (UCSC) Chr 9: 91.41 – 91.42 Mb Chr 13: 53.12 – 53.14 Mb PubMed search [3] [4]
Wikidata
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Function

Expression of interleukin-3 (IL-3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.^[5][6]