NFIX

Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene.^[5][6][7] NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.^[8]

NFIX
Identifiers
Aliases	NFIX, MRSHSS, NF1A, SOTOS2, nuclear factor I X, NF1-X, NF-I/X, CTF, MALNS
External IDs	OMIM: 164005; MGI: 97311; HomoloGene: 1872; GeneCards: NFIX; OMA:NFIX - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,995,475 bp[1] End 13,098,796 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C2|8 41.02 cM Start 84,699,876 bp[2] End 84,800,344 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple ganglionic eminence inferior ganglion of vagus nerve postcentral gyrus internal globus pallidus ventral tegmental area tendon of biceps brachii buccal mucosa cell cardia urethra Top expressed in Rostral migratory stream internal carotid artery external carotid artery ankle utricle tunica media of zone of aorta subiculum ascending aorta lacrimal gland vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process DNA replication regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4784 18032 Ensembl ENSG00000008441 ENSMUSG00000001911 UniProt Q14938 P70257 RefSeq (mRNA) NM_001271043 NM_001271044 NM_002501 NM_001365902 NM_001365982 NM_001365983 NM_001365984 NM_001365985 NM_001378404 NM_001378405 NM_001081981 NM_001081982 NM_001297601 NM_010906 RefSeq (protein) NP_001257972 NP_001257973 NP_002492 NP_001352831 NP_001352911 NP_001352912 NP_001352913 NP_001352914 NP_001365333 NP_001365334 NP_001075450 NP_001075451 NP_001284530 NP_035036 NP_001357981 NP_001357982 NP_001357983 NP_001357984 NP_001357985 NP_001357986 NP_001357987 NP_001357988 NP_001357989 NP_001357990 NP_001357991 NP_001357992 Location (UCSC) Chr 19: 13 – 13.1 Mb Chr 8: 84.7 – 84.8 Mb PubMed search [3] [4]
Wikidata
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Interactions

Nfix has been shown to interact with SKI protein^[9] and it is also known to interact with AP-1.^[8] NFI-X3 has been shown to interact with STAT3.^[8]

In embryonic cells, Nfix has been shown to regulate intermediate progenitor cell (IPC) generation by promoting the transcription of the protein inscuteable (INSC). INSC regulates spindle orientation to facilitate the division of radial glia cells into IPC's. Nfix is thought to be necessary for the commitment of glia progeny into the intermediate progenitors. Mutations may cause overproduction of radial glia, impaired and improperly timed IPC development, and underproduction of neurons. ^[10]

In adult development, the timing of neural differentiation is regulated by Nfix to promote ongoing growth of the hippocampus and proper memory function. Nfix may suppress oligodendrocyte expression so cells remain committed to neuron development within the dentate gyrus. Intermediate progenitor cells can divide to produce neuroblasts. Neurons produced by Nfix null IPC's do not mature, usually die, and can contribute to cognitive impairments.^[11]

Nfix interacts with myostatin and regulates temporal progression of muscle regeneration through modulation of myostatin expression. Nfix also inhibits the slow-twitch muscle phenotype.^[12][13]