NKG7

Natural killer cell granule protein 7 (NKG7 protein) is a protein that in humans is encoded by the NKG7 gene. ^[5] The protein is under study regarding potential in cancer research into T cell activity.^[6] A role of the NKG7 protein in regulating cell resistance and fighting tumors in certain types of cancer is being studied because of its ability to recognize and kill cancer cells through CD8+ T cell resilience that is essential for anti-tumor activity. The research suggests that the NKG7 protein allows the CD8+ T cells to continue killing malignant cells in certain circumstances and may prevent growth and metastasis of the malignant cells being attacked by the CD8+ T cells.

NKG7
Identifiers
Aliases	NKG7, GIG1, GMP-17, p15-TIA-1, natural killer cell granule protein 7
External IDs	OMIM: 606008; MGI: 1931250; HomoloGene: 4092; GeneCards: NKG7; OMA:NKG7 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,371,606 bp[1] End 51,372,701 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 43,086,497 bp[2] End 43,087,673 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte testicle blood bone marrow spleen bone marrow cell mononuclear cell monocyte trabecular bone lymph node Top expressed in tibiofemoral joint blood mesenteric lymph nodes granulocyte spleen embryo thymus bone marrow intestinal villus gastrula More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 4818 72310 Ensembl ENSG00000105374 ENSMUSG00000004612 UniProt Q16617 Q99PA5 RefSeq (mRNA) NM_005601 NM_001363693 NM_024253 RefSeq (protein) NP_005592 NP_001350622 n/a Location (UCSC) Chr 19: 51.37 – 51.37 Mb Chr 7: 43.09 – 43.09 Mb PubMed search [3] [4]
Wikidata
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