NKRF (gene)

NF-kappa-B-repressing factor is a protein that in humans is encoded by the NKRF gene.^[5][6]

NKRF
Identifiers
Aliases	NKRF, ITBA4, NRF, NFKB repressing factor
External IDs	OMIM: 300440; MGI: 1924536; HomoloGene: 84816; GeneCards: NKRF; OMA:NKRF - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq24 Start 119,588,337 bp[1] End 119,606,443 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A3.3 Start 36,151,193 bp[2] End 36,167,166 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in postcentral gyrus Brodmann area 23 superior frontal gyrus middle temporal gyrus gonad entorhinal cortex primary visual cortex Brodmann area 46 pons prefrontal cortex Top expressed in pontine nuclei medial vestibular nucleus dorsal tegmental nucleus ventral tegmental area lateral hypothalamus primitive streak facial motor nucleus deep cerebellar nuclei spinal cord superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding nucleic acid binding RNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus nucleolus nucleoplasm Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55922 77286 Ensembl ENSG00000186416 ENSMUSG00000044149 UniProt O15226 Q8BY02 RefSeq (mRNA) NM_001173487 NM_001173488 NM_017544 NM_029891 RefSeq (protein) NP_060014 NP_084167 Location (UCSC) Chr X: 119.59 – 119.61 Mb Chr X: 36.15 – 36.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes.

The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.^[6]