NLGN2

Neuroligin-2 is a protein that in humans is encoded by the NLGN2 gene.^[5][6][7]

NLGN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BL8
Identifiers
Aliases	NLGN2, neuroligin 2
External IDs	OMIM: 606479; MGI: 2681835; HomoloGene: 69317; GeneCards: NLGN2; OMA:NLGN2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,404,874 bp[1] End 7,419,860 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 69,713,948 bp[2] End 69,728,610 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum superior frontal gyrus right ovary primary visual cortex ganglionic eminence body of uterus right frontal lobe stromal cell of endometrium left ovary nucleus accumbens Top expressed in subiculum dorsomedial hypothalamic nucleus piriform cortex superior colliculus anterior amygdaloid area primary visual cortex internal carotid artery superior frontal gyrus cerebellar cortex cerebellar vermis More reference expression data BioGPS n/a
Gene ontology Molecular function carboxylic ester hydrolase activity neurexin family protein binding cell adhesion molecule binding signaling receptor activity identical protein binding Cellular component integral component of membrane postsynaptic membrane membrane synapse inhibitory synapse cell surface cell junction presynaptic membrane plasma membrane integral component of plasma membrane integral component of postsynaptic membrane intracellular anatomical structure spanning component of membrane glycinergic synapse dopaminergic synapse GABA-ergic synapse symmetric, GABA-ergic, inhibitory synapse integral component of postsynaptic specialization membrane Biological process neuromuscular process controlling balance neuron cell-cell adhesion positive regulation of inhibitory postsynaptic potential synapse organization modulation of chemical synaptic transmission positive regulation of protein localization to synapse gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering positive regulation of synaptic transmission, GABAergic regulation of AMPA receptor activity locomotory exploration behavior regulation of respiratory gaseous exchange by nervous system process cell-cell junction maintenance positive regulation of synaptic vesicle clustering positive regulation of synaptic transmission, glutamatergic cell adhesion positive regulation of excitatory postsynaptic potential sensory perception of pain terminal button organization protein localization to synapse positive regulation of insulin secretion positive regulation of synapse assembly inhibitory synapse assembly synapse assembly synaptic vesicle endocytosis postsynaptic membrane assembly presynaptic membrane assembly cell-cell adhesion postsynaptic specialization assembly presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57555 216856 Ensembl ENSG00000169992 ENSG00000283859 ENSMUSG00000051790 UniProt Q8NFZ4 Q69ZK9 RefSeq (mRNA) NM_020795 NM_198862 NM_001364137 RefSeq (protein) NP_065846 NP_942562 NP_001351066 Location (UCSC) Chr 17: 7.4 – 7.42 Mb Chr 11: 69.71 – 69.73 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.^[7]