NLGN4X

Neuroligin-4, X-linked is a protein that in humans is encoded by the NLGN4X gene.^[3][4]

NLGN4X
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2WQZ, 2XB6, 3BE8
Identifiers
Aliases	NLGN4X, ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4, neuroligin 4, X-linked, neuroligin 4 X-linked
External IDs	OMIM: 300427; HomoloGene: 136297; GeneCards: NLGN4X; OMA:NLGN4X - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.32-p22.31 Start 5,840,637 bp[1] End 6,228,867 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 spinal ganglia cerebellar vermis entorhinal cortex ventricular zone secondary oocyte decidua Brodmann area 46 buccal mucosa cell n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity scaffold protein binding carboxylic ester hydrolase activity neurexin family protein binding protein binding chloride ion binding cell adhesion molecule binding signaling receptor activity Cellular component integral component of membrane postsynaptic membrane membrane postsynaptic density synapse integral component of plasma membrane excitatory synapse cell surface cell junction dendrite plasma membrane intracellular anatomical structure spanning component of membrane presynapse symmetric, GABA-ergic, inhibitory synapse asymmetric, glutamatergic, excitatory synapse Biological process cell-cell junction organization organ growth neuron cell-cell adhesion brainstem development synapse organization learning cerebellum development negative regulation of excitatory postsynaptic potential presynaptic membrane assembly vocalization behavior adult behavior cell adhesion neuron differentiation social behavior synaptic vesicle endocytosis postsynaptic membrane assembly modulation of chemical synaptic transmission presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57502 n/a Ensembl ENSG00000146938 n/a UniProt Q8N0W4 n/a RefSeq (mRNA) NM_001282145 NM_001282146 NM_020742 NM_181332 n/a RefSeq (protein) NP_001269074 NP_001269075 NP_065793 NP_851849 n/a Location (UCSC) Chr X: 5.84 – 6.23 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

In the human brain, the synaptic protein NLGN4 is primarily expressed in the cerebral cortex.^[5]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.^[4]