NLRP4

NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.^[5][6][7]

NLRP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EWI
Identifiers
Aliases	NLRP4, CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2, NLR family, pyrin domain containing 4, NLR family pyrin domain containing 4
External IDs	OMIM: 609645; MGI: 1890518; HomoloGene: 75315; GeneCards: NLRP4; OMA:NLRP4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.43 Start 55,836,540 bp[1] End 55,881,855 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 6,048,160 bp[2] End 6,108,149 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte testicle gonad sperm right testis left testis lymph node appendix tonsil epithelium of nasopharynx Top expressed in primary oocyte zygote secondary oocyte blastocyst embryo blastocyst morula spermatid Gonadal ridge embryo More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding ATP binding Cellular component cytosol Biological process inflammatory response regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 147945 83564 Ensembl ENSG00000160505 ENSMUSG00000034690 UniProt Q96MN2 Q3TKR3 RefSeq (mRNA) NM_134444 NM_031389 RefSeq (protein) NP_604393 NP_113566 Location (UCSC) Chr 19: 55.84 – 55.88 Mb Chr 7: 6.05 – 6.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.

The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM]^[7]