NME3

Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene.^[5][6]

NME3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZS6
Identifiers
Aliases	NME3, DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2, NME/NM23 nucleoside diphosphate kinase 3
External IDs	OMIM: 601817; MGI: 1930182; HomoloGene: 20562; GeneCards: NME3; OMA:NME3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,770,320 bp[1] End 1,771,561 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 25,115,474 bp[2] End 25,116,496 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right hemisphere of cerebellum right adrenal gland left adrenal cortex right adrenal cortex right uterine tube canal of the cervix gastric mucosa left uterine tube muscle layer of sigmoid colon Top expressed in bone marrow pancreas adrenal gland islet of Langerhans urinary bladder embryo proximal tubule right kidney epiblast Hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity nucleotide binding transferase activity protein binding ATP binding metal ion binding nucleoside diphosphate kinase activity Cellular component cytosol intracellular anatomical structure Biological process UTP biosynthetic process apoptotic process CTP biosynthetic process GTP biosynthetic process nucleotide metabolic process nucleoside diphosphate phosphorylation phosphorylation nucleobase-containing small molecule interconversion regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4832 79059 Ensembl ENSG00000103024 ENSMUSG00000073435 UniProt Q13232 Q9WV85 RefSeq (mRNA) NM_002513 NM_019730 RefSeq (protein) NP_002504 NP_062704 Location (UCSC) Chr 16: 1.77 – 1.77 Mb Chr 17: 25.12 – 25.12 Mb PubMed search [3] [4]
Wikidata
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Interactions

NME3 has been shown to interact with NME1^[7][8] and NME2.^[8][9]

Clinical significance

Mutations in this gene have been associated with congenital hypotonia, hypoventilation and cerebellar histopathological alterations.^[10]