NMNAT2

Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is an enzyme that in humans is encoded by the NMNAT2 gene.^[5][6][7]

NMNAT2
Identifiers
Aliases	NMNAT2, C1orf15, PNAT2, nicotinamide nucleotide adenylyltransferase 2
External IDs	OMIM: 608701; MGI: 2444155; HomoloGene: 75037; GeneCards: NMNAT2; OMA:NMNAT2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 183,248,237 bp[1] End 183,418,380 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G3 Start 152,830,744 bp[2] End 152,995,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus frontal pole paraflocculus of cerebellum Brodmann area 10 orbitofrontal cortex cerebellar vermis Brodmann area 23 right hemisphere of cerebellum Brodmann area 46 superior frontal gyrus Top expressed in medial dorsal nucleus cerebellar cortex visual cortex superior cervical ganglion dentate gyrus of hippocampal formation granule cell central gray substance of midbrain dorsomedial hypothalamic nucleus lateral geniculate nucleus primary visual cortex cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding nucleotidyltransferase activity catalytic activity nicotinamide-nucleotide adenylyltransferase activity ATP binding nicotinate-nucleotide adenylyltransferase activity Cellular component cytoplasm Golgi membrane late endosome Golgi apparatus trans-Golgi network synapse membrane axon cytoplasmic vesicle membrane cytoplasmic vesicle cell projection Biological process pyridine nucleotide biosynthetic process NAD metabolic process biosynthesis NAD biosynthetic process 'de novo' NAD biosynthetic process from aspartate nucleotide biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23057 226518 Ensembl ENSG00000157064 ENSMUSG00000042751 UniProt Q9BZQ4 Q8BNJ3 RefSeq (mRNA) NM_170706 NM_015039 NM_175460 RefSeq (protein) NP_055854 NP_733820 NP_780669 Location (UCSC) Chr 1: 183.25 – 183.42 Mb Chr 1: 152.83 – 153 Mb PubMed search [3] [4]
Wikidata
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This gene product belongs to the nicotinamide-nucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in the nicotinamide adenine dinucleotide (NAD+ (NADP)) biosynthetic pathway. NMNAT2 is cytoplasmic (associated with the Golgi apparatus),^[8] and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Loss of NMNAT2 initiates Wallerian degeneration.^[9] By contrast, NMNAT2 enhancement opposes the actions of SARM1 which would lead to axon degeneration,^[10] but this effect is not due to preventing SARM1 depletion of NAD+.^[9] Mice lacking NMNAT2 die before birth,^[11] but are completely rescued by SARM1 deletion.^[12] Activation of NMNAT2 by Sirtuin 3 (SIRT3) may be a means of inhibiting axon degeneration and dysfunction.^[13]

The catechin epigallocatechin gallate (EGCG) found in tea can activate NMNAT2 by more than 100%.^[14]