Neuromedin U receptor 2

Neuromedin-U receptor 2 is a protein that in humans is encoded by the NMUR2 gene.^[5][6][7]

NMUR2
Identifiers
Aliases	NMUR2, FM-4, FM4, NMU-R2, NMU2R, TGR-1, TGR1, Neuromedin U receptor 2
External IDs	OMIM: 605108; MGI: 2441765; HomoloGene: 49618; GeneCards: NMUR2; OMA:NMUR2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 152,391,546 bp[1] End 152,433,368 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 55,915,813 bp[2] End 55,931,836 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle testicle mucosa of ileum deltoid muscle corpus callosum skin of thigh C1 segment internal globus pallidus right testis right lung Top expressed in embryo submandibular gland cervix jejunum duodenum skin of abdomen trachea stomach More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding signal transducer activity neuromedin U binding neuropeptide receptor activity neuromedin U receptor activity intracellular calcium activated chloride channel activity GTP binding G protein-coupled receptor activity Cellular component integral component of membrane membrane plasma membrane intracellular anatomical structure Biological process reduction of food intake in response to dietary excess calcium ion transport phospholipase C-activating G protein-coupled receptor signaling pathway activation of phospholipase A2 activity feeding behavior inositol phosphate-mediated signaling regulation of smooth muscle contraction arachidonic acid secretion positive regulation of cytosolic calcium ion concentration cell-cell signaling response to pain calcium-mediated signaling signal transduction grooming behavior central nervous system development G protein-coupled receptor signaling pathway neuropeptide signaling pathway ion transmembrane transport regulation of sensory perception of pain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56923 216749 Ensembl ENSG00000132911 ENSMUSG00000037393 UniProt Q9GZQ4 Q8BZ39 RefSeq (mRNA) NM_020167 NM_153079 RefSeq (protein) NP_064552 NP_694719 Location (UCSC) Chr 5: 152.39 – 152.43 Mb Chr 11: 55.92 – 55.93 Mb PubMed search [3] [4]
Wikidata
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Ligands

Agonists

• synephrine^[8]

See also

• Neuromedin U receptor