NOL3

Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene.^[5][6]

NOL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UZ0
Identifiers
Aliases	NOL3, ARC, FCM, MYP, NOP, NOP30, nucleolar protein 3, MYOCL1
External IDs	OMIM: 605235; MGI: 1925938; HomoloGene: 31208; GeneCards: NOL3; OMA:NOL3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,170,154 bp[1] End 67,175,735 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.04 cM Start 106,002,772 bp[2] End 106,008,571 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle skin of abdomen right adrenal gland right adrenal cortex skin of leg left adrenal gland body of pancreas muscle of thigh left adrenal cortex Top expressed in lumbar spinal ganglion extraocular muscle triceps brachii muscle sternocleidomastoid muscle temporal muscle digastric muscle ankle muscle of thigh thoracic diaphragm right ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function death effector domain binding calcium ion binding death receptor binding metal ion binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein binding RNA binding identical protein binding signaling receptor binding caspase binding Cellular component cytosol membrane sarcoplasmic reticulum sarcoplasm nucleus mitochondrion nucleolus cytoplasm Biological process regulation of apoptotic process release of sequestered calcium ion into cytosol by sarcoplasmic reticulum response to hypoxia negative regulation of striated muscle cell apoptotic process inhibition of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of muscle atrophy negative regulation of release of cytochrome c from mitochondria response to injury involved in regulation of muscle adaptation negative regulation of extrinsic apoptotic signaling pathway mRNA processing negative regulation of apoptotic process cardiac muscle cell apoptotic process intrinsic apoptotic signaling pathway negative regulation of cardiac muscle cell apoptotic process blood vessel remodeling response to ischemia mRNA splice site selection protein complex oligomerization negative regulation of mitochondrial membrane permeability involved in apoptotic process regulation of gene expression negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of necrotic cell death apoptotic process RNA splicing negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8996 78688 Ensembl ENSG00000140939 ENSMUSG00000014776 UniProt O60936 Q9D1X0 RefSeq (mRNA) NM_001185057 NM_001185058 NM_001276307 NM_001276309 NM_001276311 NM_001276312 NM_001276319 NM_003946 NM_030152 RefSeq (protein) NP_001171986 NP_001263236 NP_001263238 NP_001263240 NP_001263241 NP_001263248 NP_003937 NP_084428 Location (UCSC) Chr 16: 67.17 – 67.18 Mb Chr 8: 106 – 106.01 Mb PubMed search [3] [4]
Wikidata
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Nol3 has been shown to be induced in multiple cancer types and acts as a repressor of apoptosis leading to resistance and proliferation.^[7][8] Paradoxically, loss of Nol3 also leads to hematological disruption in mice resulting in a myeloproliferative neoplasm resembling primary myelofibrosis (PMF), and its deletion has also been detected in patient samples of PMF. ^[9]

Interactions

NOL3 has been shown to interact with SFRS9^[10] and Caspase 8.^[5]