NOL6

Nucleolar protein 6 is a protein that in humans is encoded by the NOL6 gene.^[5][6][7]

NOL6
Identifiers
Aliases	NOL6, NRAP, UTP22, bA311H10.1, nucleolar protein 6
External IDs	OMIM: 611532; MGI: 2140151; HomoloGene: 41505; GeneCards: NOL6; OMA:NOL6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 33,461,353 bp[1] End 33,473,930 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 41,114,427 bp[2] End 41,124,455 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart olfactory zone of nasal mucosa nasal epithelium gastrocnemius muscle skin of leg right testis left testis tendon of biceps brachii skin of abdomen anterior pituitary Top expressed in primary visual cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus tibiofemoral joint gastrula epiblast right ventricle yolk sac cerebellar cortex tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component condensed nuclear chromosome small-subunit processome nucleolus mitochondrion nucleus CURI complex chromosome UTP-C complex nucleoplasm Biological process tRNA export from nucleus rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65083 230082 Ensembl ENSG00000165271 ENSMUSG00000028430 UniProt Q9H6R4 Q8R5K4 RefSeq (mRNA) NM_139235 NM_022917 NM_130793 NM_139236 NM_139237 RefSeq (protein) NP_075068 NP_631981 NP_631982 Location (UCSC) Chr 9: 33.46 – 33.47 Mb Chr 4: 41.11 – 41.12 Mb PubMed search [3] [4]
Wikidata
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The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.^[7]