NOMO1

Nodal modulator 1 is a protein that in humans is encoded by the NOMO1 gene.^[5][6][7]

NOMO1
Identifiers
Aliases	NOMO1, Nomo, PM5, NODAL modulator 1
External IDs	OMIM: 609157; MGI: 2385850; HomoloGene: 13810; GeneCards: NOMO1; OMA:NOMO1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.11 Start 14,833,721 bp[1] End 14,896,157 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 29.66 cM Start 45,683,122 bp[2] End 45,733,636 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans superior frontal gyrus body of pancreas primary visual cortex stromal cell of endometrium corpus callosum nucleus accumbens right auricle of heart Brodmann area 9 Achilles tendon Top expressed in otic placode saccule entorhinal cortex perirhinal cortex Ileal epithelium crypt of lieberkuhn of small intestine lactiferous gland choroid plexus of fourth ventricle CA3 field otic vesicle More reference expression data BioGPS n/a
Gene ontology Molecular function carbohydrate binding molecular function Cellular component membrane integral component of membrane endoplasmic reticulum membrane Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23420 211548 Ensembl ENSG00000103512 ENSMUSG00000030835 UniProt Q15155 Q6GQT9 RefSeq (mRNA) NM_014287 NM_153057 RefSeq (protein) NP_055102 NP_694697 Location (UCSC) Chr 16: 14.83 – 14.9 Mb Chr 7: 45.68 – 45.73 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE).^[7]