NOX3

NADPH oxidase 3 is an enzyme that in humans is encoded by the NOX3 gene.^[5][6][7]

NOX3
Identifiers
Aliases	NOX3, GP91-3, MOX-2, NADPH oxidase 3
External IDs	OMIM: 607105; MGI: 2681162; HomoloGene: 49435; GeneCards: NOX3; OMA:NOX3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 155,395,368 bp[1] End 155,455,839 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 2.05 cM Start 3,685,515 bp[2] End 3,746,536 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Cortex of frontal lobe hippocampus proper right frontal lobe Top expressed in spermatid testicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity superoxide-generating NAD(P)H oxidase activity Cellular component cytoplasm integral component of membrane plasma membrane NADPH oxidase complex extracellular exosome membrane Biological process response to gravity temperature homeostasis detection of gravity otolith development superoxide anion generation defense response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50508 224480 Ensembl ENSG00000074771 ENSMUSG00000023802 UniProt Q9HBY0 Q672J9 RefSeq (mRNA) NM_015718 NM_198958 RefSeq (protein) NP_056533 NP_945196 Location (UCSC) Chr 6: 155.4 – 155.46 Mb Chr 17: 3.69 – 3.75 Mb PubMed search [3] [4]
Wikidata
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Function

NADPH oxidases, such as NOX3, are plasma membrane-associated enzymes found in many cell types. They catalyze the production of superoxide by a 1-electron reduction of oxygen, using NADPH as the electron donor.[supplied by OMIM]^[7]