NPHS2

Podocin is a protein that in humans is encoded by the NPHS2 gene.^[5][6][7]

NPHS2
Identifiers
Aliases	NPHS2, PDCN, SRN1, NPHS2 podocin, podocin, NPHS2 stomatin family member, podocin
External IDs	OMIM: 604766; MGI: 2157018; HomoloGene: 22826; GeneCards: NPHS2; OMA:NPHS2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.2 Start 179,550,539 bp[1] End 179,575,952 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G3 Start 156,138,297 bp[2] End 156,155,605 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus metanephric glomerulus human kidney testicle kidney tubule sperm gonad renal medulla right testis left testis Top expressed in glomerulus Bowman's capsule right kidney parietal layer of glomerular capsule human kidney morula thymus embryo embryo medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component extracellular exosome slit diaphragm membrane raft plasma membrane membrane intrinsic component of the cytoplasmic side of the plasma membrane cell-cell junction endoplasmic reticulum integral component of plasma membrane protein-containing complex Biological process actin cytoskeleton reorganization metanephric glomerular visceral epithelial cell development excretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7827 170484 Ensembl ENSG00000116218 ENSMUSG00000026602 UniProt Q9NP85 Q91X05 RefSeq (mRNA) NM_001297575 NM_014625 NM_130456 RefSeq (protein) NP_001284504 NP_055440 NP_569723 Location (UCSC) Chr 1: 179.55 – 179.58 Mb Chr 1: 156.14 – 156.16 Mb PubMed search [3] [4]
Wikidata
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Interactions

NPHS2 has been shown to interact with Nephrin^[8] and CD2AP.^[8]

See also

• Focal segmental glomerulosclerosis