NPR2

Natriuretic peptide receptor B (NPR2), also known as atrionatriuretic peptide receptor B and formerly as guanylate cyclase B, is an atrial natriuretic peptide receptor which in humans is encoded by the NPR2 gene.^[5]

NPR2
Identifiers
Aliases	NPR2, AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK, natriuretic peptide receptor 2, GCB, AMD1, GC-B
External IDs	OMIM: 108961; MGI: 97372; HomoloGene: 2970; GeneCards: NPR2; OMA:NPR2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 35,791,003 bp[1] End 35,809,732 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 23.05 cM Start 43,631,935 bp[2] End 43,651,244 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right hemisphere of cerebellum anterior pituitary canal of the cervix ascending aorta Descending thoracic aorta body of uterus stromal cell of endometrium left uterine tube muscle layer of sigmoid colon Top expressed in neural layer of retina soleus muscle ankle skin of external ear extraocular muscle muscle of thigh median eminence cumulus cell spinal ganglia tunica media of zone of aorta More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase activity nucleotide binding hormone binding GTP binding lyase activity identical protein binding phosphorus-oxygen lyase activity ATP binding guanylate cyclase activity natriuretic peptide receptor activity peptide hormone binding protein binding adenylate cyclase activity peptide receptor activity Cellular component integral component of membrane membrane plasma membrane guanylate cyclase complex, soluble integral component of plasma membrane intracellular anatomical structure Biological process negative regulation of meiotic cell cycle regulation of cardiac conduction intracellular signal transduction ossification negative regulation of oocyte maturation cyclic nucleotide biosynthetic process regulation of blood pressure cGMP biosynthetic process protein phosphorylation cellular response to granulocyte macrophage colony-stimulating factor stimulus bone development receptor guanylyl cyclase signaling pathway reproductive process positive regulation of cGMP-mediated signaling cGMP-mediated signaling signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4882 230103 Ensembl ENSG00000159899 ENSMUSG00000028469 UniProt P20594 Q6VVW5 RefSeq (mRNA) NM_000907 NM_003995 NM_001378923 NM_173788 NM_001355466 RefSeq (protein) NP_003986 NP_001365852 NP_776149 NP_001342395 Location (UCSC) Chr 9: 35.79 – 35.81 Mb Chr 4: 43.63 – 43.65 Mb PubMed search [3] [4]
Wikidata
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A mutation in the NPR2 gene can result in achondroplasia and disproportionate dwarfism with short limbs.^[6]

See also

• Atrial natriuretic peptide receptor
• Dwarfism