NPR3

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR3 gene.^[5]

NPR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JDN, 1JDP, 1YK0, 1YK1
Identifiers
Aliases	NPR3, ANP-C, ANPR-C, ANPRC, C5orf23, GUCY2B, NPR-C, NPRC, natriuretic peptide receptor 3, BOMOS
External IDs	OMIM: 108962; MGI: 97373; HomoloGene: 699; GeneCards: NPR3; OMA:NPR3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.3 Start 32,689,070 bp[1] End 32,791,724 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A1|15 5.83 cM Start 11,839,982 bp[2] End 11,907,373 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus metanephric glomerulus kidney tubule cardiac muscle tissue of right atrium stromal cell of endometrium renal medulla human kidney myocardium of left ventricle visceral pleura lower lobe of lung Top expressed in atrioventricular valve white adipose tissue atrium left lung lobe right lung lobe Epithelium of choroid plexus choroidal fissure ankle brown adipose tissue lactiferous gland More reference expression data BioGPS n/a
Gene ontology Molecular function hormone binding natriuretic peptide receptor activity G protein-coupled peptide receptor activity protein binding chloride ion binding peptide binding protein homodimerization activity peptide hormone binding Cellular component integral component of membrane membrane integral component of plasma membrane intracellular anatomical structure extracellular exosome protein-containing complex Biological process skeletal system development negative regulation of smooth muscle cell proliferation positive regulation of urine volume pancreatic juice secretion regulation of osteoblast proliferation regulation of blood pressure phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of nitric-oxide synthase activity phosphatidylinositol-mediated signaling osteoclast proliferation negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4883 18162 Ensembl ENSG00000113389 ENSMUSG00000022206 UniProt P17342 P70180 RefSeq (mRNA) NM_000908 NM_001204375 NM_001204376 NM_024563 NM_001363652 NM_001364458 NM_001364460 NM_001039181 NM_001286395 NM_008728 RefSeq (protein) NP_000899 NP_001191304 NP_001191305 NP_001350581 NP_001351387 NP_001351389 NP_001034270 NP_001273324 NP_032754 Location (UCSC) Chr 5: 32.69 – 32.79 Mb Chr 15: 11.84 – 11.91 Mb PubMed search [3] [4]
Wikidata
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Function

The family of natriuretic peptides elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.^[5]

See also

• Atrial natriuretic peptide receptor