NPRL2

Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.^[5][6]

NPRL2
Identifiers
Aliases	NPRL2, NPR2, NPR2L, TUSC4, NPR2-like, GATOR1 complex subunit, FFEVF2, NPR2 like, GATOR1 complex subunit
External IDs	OMIM: 607072; MGI: 1914482; HomoloGene: 4771; GeneCards: NPRL2; OMA:NPRL2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 50,347,330 bp[1] End 50,350,826 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 107,419,425 bp[2] End 107,422,905 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right hemisphere of cerebellum body of pancreas Skeletal muscle tissue of rectus abdominis muscle of thigh pituitary gland anterior pituitary prefrontal cortex right frontal lobe apex of heart Top expressed in interventricular septum primary oocyte right kidney proximal tubule spermatocyte neural tube superior frontal gyrus dentate gyrus of hippocampal formation granule cell secondary oocyte nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity protein binding GTPase activator activity Cellular component GATOR1 complex lysosome lysosomal membrane membrane Biological process negative regulation of TOR signaling cellular response to amino acid starvation negative regulation of kinase activity positive regulation of GTPase activity protein phosphorylation cellular response to nitrogen starvation positive regulation of autophagy regulation of autophagosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10641 56032 Ensembl ENSG00000114388 ENSMUSG00000010057 UniProt Q8WTW4 Q9WUE4 RefSeq (mRNA) NM_006545 NM_018879 RefSeq (protein) NP_006536 NP_061367 Location (UCSC) Chr 3: 50.35 – 50.35 Mb Chr 9: 107.42 – 107.42 Mb PubMed search [3] [4]
Wikidata
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