NPTX2

Neuronal pentraxin-2 is a protein that in humans is encoded by the NPTX2 gene.^[5][6]

NPTX2
Identifiers
Aliases	NPTX2, NARP, NP-II, NP2, neuronal pentraxin 2
External IDs	OMIM: 600750; MGI: 1858209; HomoloGene: 1892; GeneCards: NPTX2; OMA:NPTX2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 98,617,285 bp[1] End 98,629,869 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 84.58 cM Start 144,482,712 bp[2] End 144,494,288 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell anterior pituitary orbitofrontal cortex Brodmann area 46 lateral nuclear group of thalamus postcentral gyrus prefrontal cortex right testis Brodmann area 10 Descending thoracic aorta Top expressed in lumbar spinal ganglion superior frontal gyrus primary visual cortex primary oocyte secondary oocyte prefrontal cortex neural layer of retina zygote habenula epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding carbohydrate binding molecular function Cellular component extracellular region cellular component plasma membrane cytoplasmic side of plasma membrane filopodium dendrite growth cone soma glutamatergic synapse Biological process associative learning chemical synaptic transmission neuron projection development regulation of postsynaptic neurotransmitter receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4885 53324 Ensembl ENSG00000106236 ENSMUSG00000059991 UniProt P47972 O70340 RefSeq (mRNA) NM_002523 NM_016789 RefSeq (protein) NP_002514 NP_058069 Location (UCSC) Chr 7: 98.62 – 98.63 Mb Chr 5: 144.48 – 144.49 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the family of neuronal pentraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.^[6]

Clinical significance

Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD