NRD1

Nardilysin is a protein that in humans is encoded by the NRD1 gene.^[5][6][7]

NRDC
Identifiers
Aliases	NRDC, hNRD1, hNRD2, NRD1, nardilysin convertase, nardilysin
External IDs	OMIM: 602651; MGI: 1201386; HomoloGene: 68260; GeneCards: NRDC; OMA:NRDC - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 51,789,191 bp[1] End 51,878,805 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C7 Start 108,857,852 bp[2] End 108,918,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes right testis left testis muscle of thigh triceps brachii muscle gastrocnemius muscle anterior pituitary sperm Skeletal muscle tissue of biceps brachii thoracic diaphragm Top expressed in seminiferous tubule tail of embryo genital tubercle granulocyte spermatid plantaris muscle neural layer of retina muscle of thigh extensor digitorum longus muscle lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity protein binding catalytic activity metallopeptidase activity hydrolase activity metal ion binding epidermal growth factor binding metalloendopeptidase activity Cellular component cell surface cytosol mitochondrion Biological process positive regulation of membrane protein ectodomain proteolysis cell population proliferation neuromuscular junction development cell migration regulation of endopeptidase activity proteolysis negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4898 230598 Ensembl ENSG00000078618 ENSMUSG00000053510 UniProt O43847 Q8BHG1 RefSeq (mRNA) NM_001101662 NM_001242361 NM_002525 NM_146150 NM_001346554 NM_001347169 RefSeq (protein) NP_001095132 NP_001229290 NP_002516 NP_001333483 NP_001334098 NP_666262 Location (UCSC) Chr 1: 51.79 – 51.88 Mb Chr 4: 108.86 – 108.92 Mb PubMed search [3] [4]
Wikidata
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Interactions

NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.^[8]