NRXN3

Neurexin-3-alpha is a protein that in humans is encoded by the NRXN3 gene.^[5][6][7]

NRXN3
Identifiers
Aliases	NRXN3, C14orf60, neurexin 3
External IDs	OMIM: 600567; MGI: 1096389; GeneCards: NRXN3; OMA:NRXN3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3-q31.1 Start 78,170,373 bp[1] End 79,868,291 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 D3|12 42.94 cM Start 88,722,876 bp[2] End 90,334,935 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis pars compacta pars reticulata pons Brodmann area 23 cerebellar hemisphere right hemisphere of cerebellum middle temporal gyrus superior vestibular nucleus external globus pallidus Top expressed in Rostral migratory stream lateral septal nucleus piriform cortex lobe of cerebellum cerebellar vermis lateral geniculate nucleus medial geniculate nucleus anterior amygdaloid area lateral hypothalamus nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuroligin family protein binding transmembrane signaling receptor activity cell adhesion molecule binding metal ion binding signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Biological process neuron cell-cell adhesion social behavior vocalization behavior adult behavior cell adhesion learning angiogenesis signal transduction axon guidance positive regulation of synapse assembly positive regulation of synapse maturation synapse assembly neurotransmitter secretion chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9369 18191 Ensembl ENSG00000021645 ENSMUSG00000066392 UniProt Q9HDB5 Q6P9K9 Q8C985 RefSeq (mRNA) NM_001105250 NM_001272020 NM_004796 NM_138970 NM_001330195 NM_001366425 NM_001366426 NM_001198587 NM_001252074 NM_172544 RefSeq (protein) NP_001098720 NP_001258949 NP_001317124 NP_004787 NP_620426 NP_001353354 NP_001353355 NP_004787.2 NP_001185516 NP_001239003 NP_766132 NP_001239003.1 Location (UCSC) Chr 14: 78.17 – 79.87 Mb Chr 12: 88.72 – 90.33 Mb PubMed search [3] [4]
Wikidata
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Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.^[7] NRXN3 is thought to be involved in synaptic plasticity, and polymorphisms in NRXN3 have been linked to genetic predisposition towards a number of conditions such as alcohol or drug addiction,^[8][9][10] or obesity.^[11]