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NTN5

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

NTN5
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Netrin-5 (NTN5), also known as netrin-1-like protein, is a protein that in humans is encoded by the NTN5 gene.[5] Netrin-5 is included in the family of secreted laminin-related proteins.

Quick Facts Available structures, PDB ...
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Function

Netrin-5 functions are not fully clarified. However, it is believed to:

Clinical significance

A recent genome-wide association study (GWAS) has found that genetic variations in HAVCR2 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how netrin-5 mutation contributes to disease.[9]

Considering the role of NTN5 in cell migration, it is very possible that netrin-5 has an important role in human carcinogenesis, although currently no tumor type with NTN5 alterations has been identified.[10]

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References

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