NUB1

NEDD8 ultimate buster 1 is a protein that in humans is encoded by the NUB1 gene.^[5][6][7]

NUB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WJU
Identifiers
Aliases	NUB1, BS4, NUB1L, NYREN18, negative regulator of ubiquitin-like proteins 1, negative regulator of ubiquitin like proteins 1
External IDs	OMIM: 607981; MGI: 1889001; HomoloGene: 41108; GeneCards: NUB1; OMA:NUB1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.1 Start 151,341,772 bp[1] End 151,378,449 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 24,890,530 bp[2] End 24,915,376 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon mucosa of ileum tibia monocyte visceral pleura tendon of biceps brachii appendix parietal pleura islet of Langerhans rectum Top expressed in morula granulocyte seminiferous tubule dentate gyrus of hippocampal formation granule cell muscle of thigh superior frontal gyrus neural layer of retina primary visual cortex spermatid blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleus cytosol nucleolus Biological process response to tumor necrosis factor response to interferon-gamma positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process protein ubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51667 53312 Ensembl ENSG00000013374 ENSMUSG00000028954 UniProt Q9Y5A7 P54729 RefSeq (mRNA) NM_001243351 NM_016118 NM_001363529 NM_001385353 NM_001385354 NM_001385355 NM_001385356 NM_001385361 NM_016736 NM_001305264 RefSeq (protein) NP_001230280 NP_057202 NP_001350458 NP_001292193 NP_058016 Location (UCSC) Chr 7: 151.34 – 151.38 Mb Chr 5: 24.89 – 24.92 Mb PubMed search [3] [4]
Wikidata
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Function

NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a ubiquitin-like protein that covalently conjugates to cullin (see MIM 603134) family members.[supplied by OMIM]^[7]

Interactions

NUB1 has been shown to interact with NEDD8,^[8][9] UBD^[8] and AIPL1.^[10]