NUBP2

Nucleotide-binding protein 2 (NBP 2) also known as cytosolic Fe-S cluster assembly factor NUBP2 is a protein that in humans is encoded by the NUBP2 gene.^[5]

NUBP2
Identifiers
Aliases	NUBP2, CFD1, NBP 2, NUBP1, nucleotide binding protein 2, CIAO6, NUBP iron-sulfur cluster assembly factor 2, cytosolic
External IDs	OMIM: 610779; MGI: 1347072; HomoloGene: 8057; GeneCards: NUBP2; OMA:NUBP2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,782,932 bp[1] End 1,789,186 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 12.53 cM Start 24,882,611 bp[2] End 24,886,349 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus right lobe of liver right hemisphere of cerebellum apex of heart muscle of thigh fundus body of pancreas right adrenal gland gastrocnemius muscle left adrenal cortex Top expressed in spermatocyte seminiferous tubule spermatid right kidney morula fetal liver hematopoietic progenitor cell yolk sac blastocyst embryo proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function 4 iron, 4 sulfur cluster binding iron-sulfur cluster binding protein binding ATP binding metal ion binding nucleotide binding Cellular component cytoplasm centriole cell projection spindle pole centrosome cilium cytoskeleton nucleus microtubule organizing center cytosol Biological process cell projection organization iron-sulfur cluster assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10101 26426 Ensembl ENSG00000095906 ENSMUSG00000039183 UniProt Q9Y5Y2 Q9R061 RefSeq (mRNA) NM_001284501 NM_001284502 NM_012225 NM_011956 NM_001355396 RefSeq (protein) NP_001271430 NP_001271431 NP_036357 NP_036086 NP_001342325 Location (UCSC) Chr 16: 1.78 – 1.79 Mb Chr 17: 24.88 – 24.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ParA/MinD ATPase like
Identifiers
Symbol	ParA
Pfam	PF10609
InterPro	IPR019591
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

NUBP2 is a member of the NUBP/MRP gene subfamily of ATP-binding proteins.^[6] There are two types in eukaryotes NUBP1 and NUBP2, and one novel human gene that define NBP nucleotide-binding proteins (NUBP/MRP-multidrug resistance-associated protein)^[5] in mammalian cells requires the maturation of cytosolic^[7] iron-sulfur (Fe/S)^[8] proteins as Nubp1 is involved in the formation of extramitochondrial Fe/S proteins^[6] the cell division inhibitor MinD is homologous^[9] and involve two proteins components of the (FeS) protein assembly machinery closely similar cytosolic^[6] soluble^[8] P loop^[9] NTPase where Nar1^[10][11] is required for assembly,^[12] identified Cfd1p^[13][14] in cytosolic and nuclear Fe/S protein biogenesis^[8] in yeast.^[15] Nubp proteins NTPase Nbp35p.^[11][12] MinD is homologous to members in MinD of E. coli, a relative of the ParA family.^[9][16][17]

Morphology

^{Further information: Morphology (biology)}

NBP35 bacterial plasmids F (the classical Escherichia coli sex factor)^[9] is found in all nuclear genes in vegetative and gametic flagella of the unicellular green algae C. reinhardtii and nuclear Fe/S protein biogenesis required for cytosolic iron-sulfur protein assembly; MNP =MRP-like; MRP (Multiple Resistance and pH adaptation) MRP/NBP35-like P-loop NTPase similar to; and functions as minD_arch; cell division ATPase MinD, archaeal and homologue's of NUBP1. The NBP35 gene is conserved in archaea^[18] Bacteria, Metazoa, Fungi and other Eukaryotes and with considerable divergence from the yeast; Cfd1-Nbp35 Fe-S to man. In a scaffold complex^[19] protein to form large molecular assemblies that store Fe(III) and 4Fe-4S seen as secondary to defects inactivated to accomplish its functions as physiologically relevant form(s) Fe/S proteins Iron regulatory protein 1 (IRP1) is regulated through^[14] prevents deficiencies and increased mutation rates^[17] that characterized a plant P loop NTPase with sequence similarity to Nbp35 homologue's of NUBP1.^[20]

Interactions

NUBP2 has been shown to interact with...

• ACO1 Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron regulatory protein 1) (IRP1)^[14][21]
• MAPK8IP3 C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3)^[22]
• IGFALS Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS)^[22][23]
• KIF11 Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5)^[24]
• SEPP1 Selenoprotein P precursor (SeP)^[17]
• CA1 Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonic anhydrase I) (Carbonate dehydratase I) (CA-I)^[16][17][20]