Nucleobindin 2

Nucleobindin-2 is a protein that when found in humans is encoded by the NUCB2 gene.^[5][6]

NUCB2
Identifiers
Aliases	NUCB2, HEL-S-109, NEFA, nucleobindin 2
External IDs	OMIM: 608020; MGI: 1858179; HomoloGene: 3676; GeneCards: NUCB2; OMA:NUCB2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.1 Start 17,208,153 bp[1] End 17,349,974 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F1 Start 116,103,604 bp[2] End 116,139,819 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland tendon of biceps brachii bronchial epithelial cell olfactory zone of nasal mucosa seminal vesicula bone marrow cells corpus epididymis Achilles tendon trabecular bone body of pancreas Top expressed in seminal vesicula lacrimal gland salivary gland submandibular gland lobe of prostate parotid gland islet of Langerhans saccule olfactory epithelium supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding calcium ion binding protein binding metal ion binding Cellular component cytoplasm extracellular region cytosol plasma membrane Golgi apparatus extracellular exosome nuclear envelope endoplasmic reticulum membrane nucleus endoplasmic reticulum-Golgi intermediate compartment extracellular space nuclear outer membrane Biological process negative regulation of appetite Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4925 53322 Ensembl ENSG00000070081 ENSMUSG00000030659 UniProt P80303 P81117 RefSeq (mRNA) NM_005013 NM_001330227 NM_001352661 NM_001352662 NM_001352663 NM_001352664 NM_001352665 NM_001352666 NM_001352667 NM_001352668 NM_001352669 NM_001352670 NM_001352671 NM_001352672 NM_001130479 NM_016773 NM_001360375 RefSeq (protein) NP_001317156 NP_005004 NP_001339590 NP_001339591 NP_001339592 NP_001339593 NP_001339594 NP_001339595 NP_001339596 NP_001339597 NP_001339598 NP_001339599 NP_001339600 NP_001339601 NP_001123951 NP_001347304 Location (UCSC) Chr 11: 17.21 – 17.35 Mb Chr 7: 116.1 – 116.14 Mb PubMed search [3] [4]
Wikidata
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Nucleobindin-2 is a calcium-binding EF-hand protein.[supplied by OMIM]^[6]

NUCB2 is protein precursor of nesfatin-1

In the study of the evolution of nervous systems, NUCB2 together with SMIM20 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians, cnidarians, ctenophores, and sponges as well as in choanoflagellates.^[7][8]

Interactions

NUCB2 has been shown to interact with NDN.^[9]