NDN (gene)

Necdin is a protein that in humans is encoded by the NDN gene.^[5][6]

NDN
Identifiers
Aliases	NDN, HsT16328, PWCR, necdin, MAGE family member
External IDs	OMIM: 602117; MGI: 97290; HomoloGene: 20559; GeneCards: NDN; OMA:NDN - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q11.2 Start 23,685,400 bp[1] End 23,687,305 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 34.36 cM|7 C Start 61,996,317 bp[2] End 62,000,010 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell tendon of biceps brachii internal globus pallidus canal of the cervix nucleus accumbens right ovary hypothalamus left ovary urethra parietal pleura Top expressed in dorsomedial hypothalamic nucleus median eminence arcuate nucleus ventromedial nucleus paraventricular nucleus of hypothalamus superior cervical ganglion suprachiasmatic nucleus lateral hypothalamus supraoptic nucleus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding gamma-tubulin binding Cellular component cytoplasm perikaryon centrosome cell projection nucleus nucleoplasm cytosol Biological process respiratory system process genomic imprinting neurotrophin TRK receptor signaling pathway regulation of transcription, DNA-templated axonogenesis neuron development neuron migration multicellular organismal homeostasis transcription by RNA polymerase II post-embryonic development transcription, DNA-templated nervous system development respiratory gaseous exchange by respiratory system central nervous system development axon extension sensory perception of pain regulation of growth axonal fasciculation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation glial cell migration cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4692 17984 Ensembl ENSG00000182636 ENSG00000288364 ENSMUSG00000033585 UniProt Q99608 P25233 RefSeq (mRNA) NM_002487 NM_010882 RefSeq (protein) NP_002478 NP_035012 Location (UCSC) Chr 15: 23.69 – 23.69 Mb Chr 7: 62 – 62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This intronless gene is located in the Prader–Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.^[6]

Necdin is used to stimulate growth regulation and DNA-dependent transcription regulation.^[7]

Interactions

NDN (gene) has been shown to interact with:

• E2F1,^[8][9]
• HNRNPU,^[10]
• IL1A,^[11]
• Low affinity nerve growth factor receptor,^[9][12][13]
• NUCB2,^[14] and
• P53^[15]