NUDCD3

NudC domain-containing protein 3 is a protein that in humans is encoded by the NUDCD3 gene.^[5]

NUDCD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WGV
Identifiers
Aliases	NUDCD3, NudCL, NudC domain containing 3
External IDs	OMIM: 610296; MGI: 2144158; HomoloGene: 9097; GeneCards: NUDCD3; OMA:NUDCD3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,379,119 bp[1] End 44,490,658 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 6,055,691 bp[2] End 6,150,415 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex right frontal lobe Brodmann area 9 cerebellar hemisphere right hemisphere of cerebellum gastrocnemius muscle stromal cell of endometrium nucleus accumbens islet of Langerhans muscle of thigh Top expressed in dentate gyrus of hippocampal formation granule cell muscle of thigh primary visual cortex superior frontal gyrus dorsomedial hypothalamic nucleus cerebellar cortex piriform cortex temporal muscle subiculum triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding unfolded protein binding Cellular component cytoplasm cytoplasmic dynein complex Biological process protein folding cilium assembly protein localization to pericentriolar material developmental process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23386 209586 Ensembl ENSG00000015676 ENSMUSG00000053838 UniProt Q8IVD9 Q8R1N4 RefSeq (mRNA) NM_015332 NM_173748 NM_001363446 RefSeq (protein) NP_056147 NP_776109 NP_001350375 Location (UCSC) Chr 7: 44.38 – 44.49 Mb Chr 11: 6.06 – 6.15 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.^[5]