NUDT11

Diphosphoinositol polyphosphate phosphohydrolase 3-beta is an enzyme that in humans is encoded by the NUDT11 gene.^[5][6]

NUDT11
Identifiers
Aliases	NUDT11, APS1, ASP1, DIPP3b, DIPP3beta, hDIPP3beta, nudix hydrolase 11
External IDs	OMIM: 300528; MGI: 1930957; HomoloGene: 86995; GeneCards: NUDT11; OMA:NUDT11 - orthologs
EC number	3.6.1.60
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.22 Start 51,490,011 bp[1] End 51,496,592 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A1.1 Start 5,959,507 bp[2] End 5,967,164 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in orbitofrontal cortex Brodmann area 23 embryo ganglionic eminence middle temporal gyrus gonad right testis superior frontal gyrus oocyte secondary oocyte Top expressed in arcuate nucleus dorsomedial hypothalamic nucleus median eminence ventromedial nucleus suprachiasmatic nucleus paraventricular nucleus of hypothalamus barrel cortex supraoptic nucleus yolk sac ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity inositol diphosphate tetrakisphosphate diphosphatase activity inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity hydrolase activity metal ion binding inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity inositol bisdiphosphate tetrakisphosphate diphosphatase activity endopolyphosphatase activity diphosphoinositol-polyphosphate diphosphatase activity bis(5'-adenosyl)-hexaphosphatase activity bis(5'-adenosyl)-pentaphosphatase activity m7G(5')pppN diphosphatase activity Cellular component intracellular anatomical structure nucleus cytoplasm cytosol Biological process inositol phosphate metabolic process diphosphoinositol polyphosphate metabolic process diadenosine pentaphosphate catabolic process diadenosine hexaphosphate catabolic process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55190 58242 Ensembl ENSG00000196368 ENSMUSG00000073295 UniProt Q96G61 P0C027 P0C028 RefSeq (mRNA) NM_018159 NM_021431 RefSeq (protein) NP_060629 NP_001026834 NP_067406 NP_067406 Location (UCSC) Chr X: 51.49 – 51.5 Mb Chr X: 5.96 – 5.97 Mb PubMed search [3] [4]
Wikidata
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NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates.^[6]