NUDT2

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] is an enzyme that in humans is encoded by the NUDT2 gene.^[5][6][7]

NUDT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XSA, 1XSB, 1XSC, 3U53, 4ICK, 4IJX
Identifiers
Aliases	NUDT2, APAH1, nudix hydrolase 2, IDDPN
External IDs	OMIM: 602852; MGI: 1913651; HomoloGene: 896; GeneCards: NUDT2; OMA:NUDT2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 34,329,506 bp[1] End 34,343,711 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 41,465,151 bp[2] End 41,480,926 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium C1 segment islet of Langerhans apex of heart right adrenal cortex body of pancreas left adrenal cortex prefrontal cortex nucleus accumbens muscle of thigh Top expressed in barrel cortex facial motor nucleus olfactory epithelium saccule migratory enteric neural crest cell intercostal muscle ectoderm otic vesicle otic placode atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding bis(5'-nucleosyl)-tetraphosphatase activity GTP binding bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity protein binding hydrolase activity bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Cellular component mitochondrial matrix Biological process nucleobase-containing compound metabolic process apoptotic process cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 318 66401 Ensembl ENSG00000164978 ENSMUSG00000028443 UniProt P50583 P56380 RefSeq (mRNA) NM_147173 NM_001161 NM_001244390 NM_147172 NM_025539 RefSeq (protein) NP_001152 NP_001231319 NP_671701 NP_671702 NP_079815 Location (UCSC) Chr 9: 34.33 – 34.34 Mb Chr 4: 41.47 – 41.48 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified.^[7]