NUDT4

Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.^[5][6][7]

NUDT4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DUK
Identifiers
Aliases	NUDT4, DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P, nudix hydrolase 4, DIPP-2B, NUDT4B
External IDs	OMIM: 609229; MGI: 1918457; HomoloGene: 41726; GeneCards: NUDT4; OMA:NUDT4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q22 Start 93,377,883 bp[1] End 93,408,146 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C2 Start 95,382,869 bp[2] End 95,400,008 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle parotid gland myocardium of left ventricle renal medulla caput epididymis corpus epididymis cardiac muscle tissue of right atrium gallbladder trabecular bone mucosa of sigmoid colon Top expressed in molar ciliary body endocardial cushion submandibular gland left colon granulocyte seminiferous tubule atrium quadriceps femoris muscle knee joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inositol diphosphate tetrakisphosphate diphosphatase activity inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity metal ion binding protein binding RNA binding inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity hydrolase activity diphosphoinositol-polyphosphate diphosphatase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity inositol bisdiphosphate tetrakisphosphate diphosphatase activity endopolyphosphatase activity bis(5'-adenosyl)-hexaphosphatase activity bis(5'-adenosyl)-pentaphosphatase activity m7G(5')pppN diphosphatase activity snoRNA binding Cellular component intracellular anatomical structure nucleus cytoplasm cytosol Biological process intracellular signal transduction cyclic nucleotide metabolic process inositol phosphate metabolic process cyclic-nucleotide-mediated signaling calcium-mediated signaling diphosphoinositol polyphosphate metabolic process diadenosine pentaphosphate catabolic process diadenosine hexaphosphate catabolic process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11163 71207 Ensembl ENSG00000173598 ENSMUSG00000020029 UniProt Q9NZJ9 Q8R2U6 RefSeq (mRNA) NM_001301022 NM_001301023 NM_001301024 NM_019094 NM_199040 NM_027722 NM_001358996 RefSeq (protein) NP_001287951 NP_001287952 NP_001287953 NP_061967 NP_950241 NP_081998 NP_001345925 Location (UCSC) Chr 12: 93.38 – 93.41 Mb Chr 10: 95.38 – 95.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.^[7]