NUDT6

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene.^[5][6][7]

NUDT6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FXT, 3H95
Identifiers
Aliases	NUDT6, ASFGF2, FGF-AS, FGF2AS, GFG-1, GFG1, nudix hydrolase 6
External IDs	OMIM: 606261; MGI: 2387618; HomoloGene: 31425; GeneCards: NUDT6; OMA:NUDT6 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q28.1 Start 122,888,697 bp[1] End 122,922,968 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 37,459,059 bp[2] End 37,474,360 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii internal globus pallidus right lobe of liver germinal epithelium oocyte left ventricle right adrenal gland right adrenal cortex right ventricle left adrenal gland Top expressed in interventricular septum aortic valve ascending aorta right kidney muscle of thigh proximal tubule masseter muscle myocardium of ventricle skeletal muscle tissue sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function growth factor activity hydrolase activity NADH pyrophosphatase activity ADP-ribose diphosphatase activity NAD binding Cellular component cytoplasm mitochondrion nucleus cellular component Biological process regulation of signaling receptor activity biological process negative regulation of cell population proliferation negative regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11162 229228 Ensembl ENSG00000170917 ENSMUSG00000050174 UniProt P53370 Q8CH40 RefSeq (mRNA) NM_198041 NM_007083 NM_001291044 NM_153561 RefSeq (protein) NP_009014 NP_932158 NP_001277973 NP_705789 Location (UCSC) Chr 4: 122.89 – 122.92 Mb Chr 3: 37.46 – 37.47 Mb PubMed search [3] [4]
Wikidata
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FGF2 (MIM 134920) is a highly conserved, multifunctional heparin-binding growth factor involved in neuroectoderm development, angiogenesis, and wound healing.

Elevated levels of FGF2 are associated with proliferation of smooth muscle in atherosclerosis and with proliferation of tumors. The FGF2 antisense gene, NUDT6, may regulate FGF2 expression.[supplied by OMIM]^[7]