Nuclear mitotic apparatus protein 1

Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.^[5][6]

NUMA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RO2
Identifiers
Aliases	NUMA1, NUMA, NMP-22, nuclear mitotic apparatus protein 1
External IDs	OMIM: 164009; MGI: 2443665; HomoloGene: 38150; GeneCards: NUMA1; OMA:NUMA1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,002,864 bp[1] End 72,080,693 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 101,583,318 bp[2] End 101,664,171 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube body of uterus canal of the cervix left ovary right ovary gastric mucosa muscle layer of sigmoid colon ectocervix right lobe of thyroid gland ventricular zone Top expressed in genital tubercle Rostral migratory stream ventricular zone vas deferens neural layer of retina cumulus cell efferent ductule Gonadal ridge thymus internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity protein binding microtubule binding protein C-terminus binding tubulin binding phosphatidylinositol binding microtubule plus-end binding microtubule minus-end binding dynein complex binding disordered domain specific binding lipid binding protein domain specific binding protein-containing complex binding Cellular component extracellular exosome spindle mitotic spindle chromosome microtubule organizing center Golgi membrane apical part of cell mitotic spindle astral microtubule centrosome microtubule soma dendrite cytoskeleton spindle microtubule spindle pole nucleus cytoplasm cytosol nuclear matrix extrinsic component of plasma membrane spindle pole centrosome microtubule plus-end microtubule minus-end cortical microtubule microtubule bundle mitotic spindle pole cell cortex region cytoplasmic microtubule bundle mitotic spindle midzone nucleoplasm plasma membrane cell cortex membrane lateral cell cortex lateral plasma membrane protein-containing complex Biological process lung epithelial cell differentiation cell cycle cell division meiosis nucleus organization establishment of mitotic spindle orientation microtubule bundle formation positive regulation of BMP signaling pathway astral microtubule organization positive regulation of microtubule polymerization positive regulation of intracellular transport positive regulation of keratinocyte differentiation positive regulation of hair follicle development positive regulation of chromosome segregation anastral spindle assembly regulation of mitotic spindle organization regulation of metaphase plate congression positive regulation of protein localization to spindle pole body positive regulation of mitotic spindle elongation positive regulation of protein localization to cell cortex positive regulation of chromosome separation positive regulation of spindle assembly chromosome segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4926 101706 Ensembl ENSG00000137497 ENSMUSG00000066306 UniProt Q14980 Q3SYK8 E9Q7G0 RefSeq (mRNA) NM_001286561 NM_006185 NM_133947 RefSeq (protein) NP_001273490 NP_006176 NP_006176.2 NP_598708 NP_001390473 NP_001390474 NP_001390475 NP_001390476 NP_001390477 NP_001390478 NP_001390479 NP_001390480 NP_001390481 NP_001390482 Location (UCSC) Chr 11: 72 – 72.08 Mb Chr 7: 101.58 – 101.66 Mb PubMed search [3] [4]
Wikidata
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Interactions

Nuclear mitotic apparatus protein 1 has been shown to interact with PIM1,^[7] Band 4.1,^[8] GPSM2^[9] and EPB41L1.^[10]