NUTF2

Nuclear transport factor 2 is a protein that in humans is encoded by the NUTF2 gene.^[4][5][6]

NUTF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GY5,%%s1GY6, 5BXQ, 1A2K, 1OUN
Identifiers
Aliases	NUTF2, NTF2, PP15, NTF-2, nuclear transport factor 2
External IDs	OMIM: 605813; MGI: 3704482; HomoloGene: 110745; GeneCards: NUTF2; OMA:NUTF2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,846,923 bp[1] End 67,872,567 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh ascending aorta popliteal artery tibial arteries left coronary artery C1 segment Descending thoracic aorta right coronary artery anterior cingulate cortex stromal cell of endometrium n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural constituent of nuclear pore identical protein binding nuclear import signal receptor activity Cellular component cytoplasm nuclear pore central transport channel nuclear outer membrane intracellular anatomical structure extracellular exosome nucleus nuclear inner membrane nuclear pore nucleoplasm cytosol membrane nuclear membrane Biological process negative regulation of vascular endothelial growth factor production protein transport positive regulation of protein import into nucleus protein export from nucleus protein import into nucleus mRNA transport protein localization to nuclear pore transport nucleocytoplasmic transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10204 621832 Ensembl ENSG00000102898 n/a UniProt P61970 P61971 RefSeq (mRNA) NM_005796 NM_001322038 NM_001322039 NM_001322040 NM_001322041 XM_001473957 RefSeq (protein) NP_001308967 NP_001308968 NP_001308969 NP_001308970 NP_005787 NP_005787.1 NP_001308967.1 NP_001308968.1 NP_001308969.1 NP_001308970.1 NP_080808 NP_001344158 NP_001344159 Location (UCSC) Chr 16: 67.85 – 67.87 Mb n/a PubMed search [2] [3]
Wikidata
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Function

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.^[6]

Interactions

NUTF2 has been shown to interact with Nucleoporin 62^[4][7] and RAN.^[8][9]