NXT1

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.^[5][6][7]

NXT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JKG, 1JN5, 4WYK
Identifiers
Aliases	NXT1, MTR2, P15, nuclear transport factor 2 like export factor 1
External IDs	OMIM: 605811; MGI: 1929619; HomoloGene: 8301; GeneCards: NXT1; OMA:NXT1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.21 Start 23,350,791 bp[1] End 23,354,771 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G3 Start 148,514,521 bp[2] End 148,517,947 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube popliteal artery tibial arteries mucosa of urinary bladder olfactory zone of nasal mucosa ascending aorta left ovary granulocyte cartilage tissue skin of abdomen Top expressed in spermatocyte seminiferous tubule spermatid embryo embryo medullary collecting duct epiblast renal corpuscle maxillary prominence primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleus nuclear speck nuclear pore nucleoplasm cytoplasm cytosol nuclear pore central transport channel Biological process protein export from nucleus protein transport RNA export from nucleus mRNA export from nucleus protein import into nucleus nucleocytoplasmic transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29107 56488 Ensembl ENSG00000132661 ENSMUSG00000036992 UniProt Q9UKK6 Q9QZV9 RefSeq (mRNA) NM_013248 NM_001110159 NM_019761 RefSeq (protein) NP_037380 NP_001103629 NP_062735 Location (UCSC) Chr 20: 23.35 – 23.35 Mb Chr 2: 148.51 – 148.52 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.^[7]