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Neuron derived neurotrophic factor

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Neuron derived neurotrophic factor
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Neuron derived neurotrophic factor (NDNF) is a secreted protein that, in humans, is located on chromosome 4.[5] This protein helps in the growth, survival, migration, and differentiation of neurons.[6] To assist with migration, NDNF shows neuro-repulsive effects on GnRH neurons. Loss of function (LoF) in the NDNF gene has been shown to be a cause of a disease known as congenital hypogonadotropic hypogonadism, which can have associated cleft lip and cleft palate.[7] A preliminary study has shown that knock-down of ndnf reduces development of the ethmoid plate, which is homologous to the human palate.[8][9]

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3D protein structure of the NDNF gene as based on an Alphafold model.
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