Neuropeptide B

Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.^[5][6] It is expressed throughout the central nervous system with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

NPB
Identifiers
Aliases	NPB, L7, PPL7, PPneuropeptide B
External IDs	OMIM: 607996; MGI: 2387153; HomoloGene: 102151; GeneCards: NPB; OMA:NPB - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 81,900,745 bp[1] End 81,902,905 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 120,499,303 bp[2] End 120,499,919 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment testicle hypothalamus substantia nigra nucleus accumbens amygdala stromal cell of endometrium Brodmann area 9 putamen anterior cingulate cortex Top expressed in stomach embryo testicle morula embryo right kidney spermatid placenta urinary bladder cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding G protein-coupled receptor binding Cellular component extracellular region Biological process neuropeptide signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 256933 208990 Ensembl ENSG00000183979 ENSMUSG00000044034 UniProt Q8NG41 Q8K4P1 RefSeq (mRNA) NM_148896 NM_153288 NM_001347616 NM_001347617 RefSeq (protein) NP_683694 NP_001334545 NP_001334546 NP_695020 Location (UCSC) Chr 17: 81.9 – 81.9 Mb Chr 11: 120.5 – 120.5 Mb PubMed search [3] [4]
Wikidata
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See also

• Neuropeptide W