Neutrophil cytosolic factor 2

Neutrophil cytosol factor 2 is a protein that in humans is encoded by the NCF2 gene.

NCF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E96, 1HH8, 1K4U, 1OEY, 1WM5, 2DMO
Identifiers
Aliases	NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX, Neutrophil cytosolic factor 2
External IDs	OMIM: 608515; MGI: 97284; HomoloGene: 374; GeneCards: NCF2; OMA:NCF2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 183,555,562 bp[1] End 183,590,876 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G3|1 65.05 cM Start 152,675,945 bp[2] End 152,712,742 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte bone marrow bone marrow cells right lung spleen trabecular bone upper lobe of left lung periodontal fiber Top expressed in granulocyte spleen bone marrow ileum jejunum colon lung ovary uterus thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function superoxide-generating NAD(P)H oxidase activity protein C-terminus binding protein binding electron transfer activity superoxide-generating NADPH oxidase activator activity Cellular component acrosomal vesicle nucleolus phagolysosome cytoplasm cytosol NADPH oxidase complex Biological process superoxide anion generation cellular defense response vascular endothelial growth factor receptor signaling pathway innate immune response superoxide metabolic process phagocytosis positive regulation of catalytic activity respiratory burst electron transport chain antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent cellular response to oxidative stress cell redox homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4688 17970 Ensembl ENSG00000116701 ENSMUSG00000026480 UniProt P19878 O70145 RefSeq (mRNA) NM_000433 NM_001127651 NM_001190789 NM_001190794 NM_010877 RefSeq (protein) NP_000424 NP_001121123 NP_001177718 NP_001177723 NP_035007 Location (UCSC) Chr 1: 183.56 – 183.59 Mb Chr 1: 152.68 – 152.71 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease.^[5]