Nucleobindin 1

Nucleobindin-1 (NUCB1), also known as calnuc, is a protein that in humans is encoded by the NUCB1 gene.^[5][6]

NUCB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SNL
Identifiers
Aliases	NUCB1, CALNUC, NUC, nucleobindin 1
External IDs	OMIM: 601323; MGI: 97388; HomoloGene: 4507; GeneCards: NUCB1; OMA:NUCB1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,900,312 bp[1] End 48,923,372 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,139,882 bp[2] End 45,159,830 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium Descending thoracic aorta right lobe of liver apex of heart ascending aorta left coronary artery right coronary artery right lobe of thyroid gland right auricle of heart upper lobe of left lung Top expressed in external carotid artery choroid plexus of fourth ventricle internal carotid artery right kidney lip calvaria large intestine colon ileum duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding calcium ion binding metal ion binding protein binding G-protein alpha-subunit binding Cellular component cytoplasm lumenal side of Golgi membrane rough endoplasmic reticulum membrane cis-Golgi network Golgi-associated vesicle Golgi cisterna membrane extracellular region extrinsic component of Golgi membrane trans-Golgi network early endosome extracellular exosome nucleus endoplasmic reticulum-Golgi intermediate compartment extracellular space Golgi apparatus endoplasmic reticulum lumen Biological process regulation of protein targeting response to cisplatin post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4924 18220 Ensembl ENSG00000104805 ENSMUSG00000030824 UniProt Q02818 Q02819 RefSeq (mRNA) NM_006184 NM_001163662 NM_008749 RefSeq (protein) NP_006175 NP_001157134 NP_032775 Location (UCSC) Chr 19: 48.9 – 48.92 Mb Chr 7: 45.14 – 45.16 Mb PubMed search [3] [4]
Wikidata
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Structure

The human calnuc protein contains 461 amino acids and has a pI of 4.9.^[7]

The protein contains the following regions and domains:

• Signal peptide^[8]
• Leucine-zipper^[8] The leucine-zipper of calnuc may be responsible for its dimerization.
• aa 347-389 – Nuclear localization signal
• 2 zinc binding sites^[9] with high affinity (K_d = 20 nM)
• carboxypeptidase-like motifs : HFREXnH (aa 66) and HFTEXnH (aa 146)
• 2 EF-hands
• Potential anchor region^[7]– 15-aa hydrophobic region at its COOH terminus that may be sufficient for membrane anchoring