GPR143

G-protein coupled receptor 143, also known as Ocular albinism type 1 (OA1) in humans, is a conserved integral membrane protein with seven transmembrane domains and similarities with G protein-coupled receptors (GPCRs) that is expressed in the eye and epidermal melanocytes.^[4][5][6] This protein encoded by the GPR143 gene,^[7][8] whose variants can lead to Ocular albinism type 1.^[9]

GPR143
Identifiers
Aliases	GPR143, NYS6, OA1, G protein-coupled receptor 143
External IDs	OMIM: 300808; MGI: 107193; HomoloGene: 230; GeneCards: GPR143; OMA:GPR143 - orthologs
Gene location (Mouse) Chr. X chromosome (mouse)[1] Band X F3|X 68.46 cM Start 151,564,917 bp[1] End 151,591,642 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte retinal pigment epithelium caudate nucleus nucleus accumbens putamen cingulate gyrus amygdala skin of abdomen Brodmann area 9 Top expressed in iris retinal pigment epithelium hair follicle ciliary body embryo stria vascularis embryo morula endothelial cell of lymphatic vessel primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function L-DOPA binding G protein-coupled receptor activity signal transducer activity dopamine binding tyrosine binding protein binding L-DOPA receptor activity Cellular component cytoplasm integral component of membrane Golgi apparatus membrane melanosome melanosome membrane lysosomal membrane apical plasma membrane lysosome plasma membrane Biological process eye pigment biosynthetic process regulation of melanosome transport melanosome localization melanosome organization melanosome transport regulation of calcium-mediated signaling regulation of melanosome organization calcium-mediated signaling using intracellular calcium source phosphatidylinositol-mediated signaling signal transduction visual perception neuropeptide signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4935 18241 Ensembl n/a ENSMUSG00000025333 UniProt P51810 P70259 RefSeq (mRNA) NM_000273 NM_010951 RefSeq (protein) NP_000264 NP_035081 Location (UCSC) n/a Chr X: 151.56 – 151.59 Mb PubMed search [2] [3]
Wikidata
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Ocular albinism type 1 protein
Identifiers
Symbol	Ocular_alb
Pfam	PF02101
Pfam clan	CL0192
InterPro	IPR001414
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.^[10][11]

L-DOPA is an endogenous ligand for OA1.^[12]

Interactions

GPR143 has been shown to interact with GNAI1.^[8]