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GPR143

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

GPR143
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G-protein coupled receptor 143, also known as Ocular albinism type 1 (OA1) in humans, is a conserved integral membrane protein with seven transmembrane domains and similarities with G protein-coupled receptors (GPCRs) that is expressed in the eye and epidermal melanocytes.[4][5][6] This protein encoded by the GPR143 gene,[7][8] whose variants can lead to Ocular albinism type 1.[9]

Quick Facts Identifiers, Aliases ...
Quick Facts Ocular albinism type 1 protein, Identifiers ...

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.[10][11]

L-DOPA is an endogenous ligand for OA1.[12]

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Interactions

GPR143 has been shown to interact with GNAI1.[8]

References

Further reading

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