GNAI1

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.^[5][6]

GNAI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KJY, 1Y3A, 2G83, 2GTP, 2IK8, 2OM2, 2XNS, 3ONW, 3QE0, 3QI2, 3UMR, 3UMS, 4G5Q, 5JS7, 5JS8
Identifiers
Aliases	GNAI1, Gi, G protein subunit alpha i1, HG1B, NEDHISB
External IDs	OMIM: 139310; MGI: 95771; HomoloGene: 74417; GeneCards: GNAI1; OMA:GNAI1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.11 Start 79,768,028 bp[1] End 80,226,181 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A3|5 8.16 cM Start 18,470,133 bp[2] End 18,565,353 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum inferior ganglion of vagus nerve pars reticulata subthalamic nucleus germinal epithelium C1 segment pons oocyte secondary oocyte superior vestibular nucleus Top expressed in substantia nigra lateral septal nucleus subiculum barrel cortex sciatic nerve nucleus accumbens white adipose tissue Region I of hippocampus proper cerebellar vermis lobe of cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activating protein binding nucleotide binding G-protein beta/gamma-subunit complex binding GDP binding G protein-coupled serotonin receptor binding signal transducer activity metal ion binding protein binding guanyl nucleotide binding G protein-coupled receptor binding GTP binding magnesium ion binding GTPase activity Cellular component cytoplasm centrosome membrane plasma membrane intracellular anatomical structure microtubule organizing center lysosomal membrane midbody heterotrimeric G-protein complex membrane raft extracellular exosome cytoskeleton nucleus nucleolus cell cortex region cell cortex protein-containing complex Biological process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway response to peptide hormone negative regulation of synaptic transmission cell division cell cycle signal transduction regulation of cAMP-mediated signaling cellular response to forskolin protein folding regulation of mitotic spindle organization positive regulation of protein localization to cell cortex transport G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2770 14677 Ensembl ENSG00000127955 ENSMUSG00000057614 UniProt P63096 B2RSH2 RefSeq (mRNA) NM_002069 NM_001256414 NM_010305 RefSeq (protein) NP_001243343 NP_002060 NP_034435 Location (UCSC) Chr 7: 79.77 – 80.23 Mb Chr 5: 18.47 – 18.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

GNAI1 has been shown to interact with:

• GPR143,^[7]
• RGS12,^[8]
• RGS14,^[8][9]
• RGS19,^[10][11]
• RIC8A,^[12] and
• S1PR1.^[13]