OAS2

2'-5'-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene.^[5][6]

OAS2
Identifiers
Aliases	OAS2, 2'-5'-oligoadenylate synthetase 2
External IDs	OMIM: 603350; MGI: 2180852; HomoloGene: 49478; GeneCards: OAS2; OMA:OAS2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.13 Start 112,978,395 bp[1] End 113,011,723 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 60.64 cM Start 120,868,398 bp[2] End 120,887,918 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte lymph node decidua appendix gallbladder spleen right lung blood olfactory zone of nasal mucosa Top expressed in mucous cell of stomach granulocyte stroma of bone marrow submandibular gland epithelium of stomach blood gastrula myocardium of ventricle subcutaneous adipose tissue cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding nucleotidyltransferase activity zinc ion binding metal ion binding 2'-5'-oligoadenylate synthetase activity protein binding RNA binding double-stranded RNA binding ATP binding Cellular component cytoplasm membrane endoplasmic reticulum mitochondrion perinuclear region of cytoplasm nucleus nucleoplasm cytosol intracellular membrane-bounded organelle Biological process purine nucleotide biosynthetic process interferon-gamma-mediated signaling pathway immune system process protein myristoylation response to virus RNA catabolic process protein glycosylation defense response to virus type I interferon signaling pathway immune response innate immune response nucleobase-containing compound metabolic process response to bacterium regulation of ribonuclease activity regulation of lactation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4939 246728 Ensembl ENSG00000111335 ENSMUSG00000032690 UniProt P29728 E9Q9A9 RefSeq (mRNA) NM_001032731 NM_002535 NM_016817 NM_145227 NM_001347448 RefSeq (protein) NP_001027903 NP_002526 NP_058197 NP_001334377 NP_660262 Location (UCSC) Chr 12: 112.98 – 113.01 Mb Chr 5: 120.87 – 120.89 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.^[6]