OAS3

This article is about the enzyme. For the computer programming specification, see OpenAPI Specification.

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.^[5][6]

OAS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4S3N
Identifiers
Aliases	OAS3, p100, p100OAS, 2'-5'-oligoadenylate synthetase 3
External IDs	OMIM: 603351; MGI: 2180850; HomoloGene: 4510; GeneCards: OAS3; OMA:OAS3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.13 Start 112,938,051 bp[1] End 112,976,460 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 60.64 cM Start 120,891,163 bp[2] End 120,915,726 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte decidua gallbladder apex of heart mucosa of esophagus appendix bone marrow cells oral cavity epithelium of colon Top expressed in granulocyte blood mucous cell of stomach intestinal villus jejunum bone marrow stroma of bone marrow zygote thymus spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding nucleotidyltransferase activity metal ion binding 2'-5'-oligoadenylate synthetase activity protein binding RNA binding double-stranded RNA binding ATP binding Cellular component cytoplasm intracellular membrane-bounded organelle plasma membrane nucleoplasm nucleus extracellular space cytosol Biological process regulation of ribonuclease activity immune system process interferon-gamma-mediated signaling pathway response to virus negative regulation of viral genome replication defense response to virus type I interferon signaling pathway immune response innate immune response nucleobase-containing compound metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4940 246727 Ensembl ENSG00000111331 ENSMUSG00000032661 UniProt Q9Y6K5 Q8VI93 RefSeq (mRNA) NM_006187 NM_145226 RefSeq (protein) NP_006178 NP_660261 Location (UCSC) Chr 12: 112.94 – 112.98 Mb Chr 5: 120.89 – 120.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of ATP. These oligomers activate latent RNase L, leading to degradation of both viral and endogenous RNA. This enzyme family plays a significant role in the inhibition of cellular protein synthesis in response to viral infection.^[6]