ODF1

Outer dense fiber protein 1 is a protein that in humans is encoded by the ODF1 gene.^[5][6]

ODF1
Identifiers
Aliases	ODF1, CT133, HSPB10, ODF, ODF2, ODF27, ODFP, ODFPG, ODFPGA, ODFPGB, RT7, SODF, outer dense fiber of sperm tails 1
External IDs	OMIM: 182878; MGI: 97424; HomoloGene: 7456; GeneCards: ODF1; OMA:ODF1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.3 Start 102,551,589 bp[1] End 102,561,018 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 15.14 cM Start 38,219,447 bp[2] End 38,226,979 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right testis left testis testicle gonad bronchial epithelial cell tail of epididymis nucleus accumbens putamen caudate nucleus Top expressed in seminiferous tubule spermatid spermatocyte embryo secondary oocyte primary oocyte white adipose tissue skeletal muscle tissue islet of Langerhans adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein domain specific binding Cellular component nucleus outer dense fiber Biological process multicellular organism development cell differentiation spermatogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4956 18285 Ensembl ENSG00000155087 ENSMUSG00000061923 UniProt Q14990 Q61999 RefSeq (mRNA) NM_024410 NM_008757 RefSeq (protein) NP_077721 NP_032783 Location (UCSC) Chr 8: 102.55 – 102.56 Mb Chr 15: 38.22 – 38.23 Mb PubMed search [3] [4]
Wikidata
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The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein.^[6]