OR1A1

Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene.^[5][6]

OR1A1
Identifiers
Aliases	OR1A1, OR17-7, olfactory receptor family 1 subfamily A member 1, olfactory receptor family 1 subfamily A member 1 (gene/pseudogene)
External IDs	OMIM: 618046; MGI: 1333770; HomoloGene: 8219; GeneCards: OR1A1; OMA:OR1A1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 3,207,539 bp[1] End 3,218,896 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 74,096,490 bp[2] End 74,102,205 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity olfactory receptor activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8383 258706 Ensembl ENSG00000172146 ENSMUSG00000070377 UniProt Q9P1Q5 n/a RefSeq (mRNA) NM_014565 NM_001386104 NM_146711 RefSeq (protein) NP_055380 n/a Location (UCSC) Chr 17: 3.21 – 3.22 Mb Chr 11: 74.1 – 74.1 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.^[6]

Ligands

OR1A1 is relatively broadly tuned, meaning it responds to a relatively wide variety of different odor molecules.^[7][8] Examples of known ligands, most of which have citrus or fruity smells:^[9][10]

• (S)-(−)-citronellal
• Helional
• Heptanal
• Octanal
• Nonanal (weaker than heptanal/octanal^[9])
• Hydroxycitronellal
• Citral
• Citronellol (both enantiomers, weaker than citronellal^[9])
• Dihydrojasmone^[7]
• Thiols^[8]

See also

• Olfactory receptor