Top Qs
Timeline
Chat
Perspective
OR1A1
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Remove ads
Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene.[5][6]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.[6]
Remove ads
Ligands
OR1A1 is relatively broadly tuned, meaning it responds to a relatively wide variety of different odor molecules.[7][8] Examples of known ligands, most of which have citrus or fruity smells:[9][10]
- (S)-(−)-citronellal
- Helional
- Heptanal
- Octanal
- Nonanal (weaker than heptanal/octanal[9])
- Hydroxycitronellal
- Citral
- Citronellol (both enantiomers, weaker than citronellal[9])
- Dihydrojasmone[7]
- Thiols[8]
See also
References
Further reading
External links
Wikiwand - on
Seamless Wikipedia browsing. On steroids.
Remove ads