OR2J3

Olfactory receptor 2J3 is a protein that in humans is encoded by the OR2J3 gene.^[5]

OR2J3
Identifiers
Aliases	OR2J3, 6M1-3, C3HEXS, HS6M1-3, OR6-16, OR6-6, OR6.3.6, ORL671, olfactory receptor family 2 subfamily J member 3
External IDs	OMIM: 615016; MGI: 2177520; HomoloGene: 128270; GeneCards: OR2J3; OMA:OR2J3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 29,108,058 bp[1] End 29,114,770 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 38,614,418 bp[2] End 38,618,461 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle sural nerve left testis right testis n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 442186 258481 Ensembl ENSG00000204701 ENSMUSG00000054940 UniProt O76001 Q8VFC2 RefSeq (mRNA) NM_001005216 NM_146488 RefSeq (protein) NP_001005216 NP_666699 Location (UCSC) Chr 6: 29.11 – 29.11 Mb Chr 17: 38.61 – 38.62 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Genetic variation

A pair of two single-nucleotide polymorphisms, both in the OR2J3 gene, strongly reduce sensitivity to the odorant cis-3-hexen-1-ol, which has a "cut grass" smell.^[6]

Ligands

• cis-3-Hexen-1-ol^[6]
• Cinnamaldehyde^[7]

See also

• Olfactory receptor