OR3A1

Olfactory receptor 3A1 is a protein that in humans is encoded by the OR3A1 gene.^[5][6][7]

OR3A1
Identifiers
Aliases	OR3A1, OLFRA03, OR17-40, OR17-82, OR40, olfactory receptor family 3 subfamily A member 1, olfactory receptor family 3 subfamily A member 1 (gene/pseudogene)
External IDs	MGI: 3030236; HomoloGene: 1915; GeneCards: OR3A1; OMA:OR3A1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 3,291,017 bp[1] End 3,298,360 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 74,044,355 bp[2] End 74,048,987 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle secondary oocyte gonad islet of Langerhans ventricular zone prefrontal cortex urinary bladder right testis left testis gallbladder n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4994 258703 Ensembl ENSG00000180090 ENSMUSG00000070379 UniProt P47881 Q8VFX8 RefSeq (mRNA) NM_002550 NM_146708 RefSeq (protein) NP_002541 NP_666919 Location (UCSC) Chr 17: 3.29 – 3.3 Mb Chr 11: 74.04 – 74.05 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[7]

Ligands

OR3A1 is activated by helional and the closely related molecule heliotropylacetone.^[8] Other compounds including piperonal, safrole, and vanillin completely failed to activate OR3A1.

Agonists:

• helional^[8]
• heliotropylacetone^[8]
• lilial^[9]
• cyclamen aldehyde^[9]
• foliaver (3-(4-methoxyphenyl)-2-methylpropanal)^[9]

See also

• Olfactory receptor