OR51E1

Olfactory receptor 51E1 is a protein that in humans is encoded by the OR51E1 gene.^[5]

OR51E1
Identifiers
Aliases	OR51E1, D-GPCR, DGPCR, GPR136, GPR164, OR51E1P, OR52A3P, POGR, PSGR2, olfactory receptor family 51 subfamily E member 1
External IDs	OMIM: 611267; MGI: 3030392; HomoloGene: 17503; GeneCards: OR51E1; OMA:OR51E1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 4,643,420 bp[1] End 4,655,488 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 102,351,422 bp[2] End 102,361,271 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte testicle tibialis anterior muscle pancreatic ductal cell apex of heart mucosa of ileum popliteal artery tibial arteries left ventricle placenta Top expressed in esophagus muscle of thigh spermatocyte right kidney spermatid artery muscle tissue skeletal muscle tissue carotid body major salivary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity olfactory receptor activity G protein-coupled receptor activity Cellular component membrane integral component of membrane plasma membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 143503 259097 Ensembl ENSG00000180785 ENSMUSG00000070423 UniProt Q8TCB6 Q8VGZ7 RefSeq (mRNA) NM_152430 NM_147093 RefSeq (protein) NP_689643 NP_667304 Location (UCSC) Chr 11: 4.64 – 4.66 Mb Chr 7: 102.35 – 102.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Ligands

The receptor is associated with some compounds with a "cheese" or "sour" scent note. Examples of compounds that activate OR51E1 include:

• butyl butyryl lactate^[6]
• isovaleric acid^[7]
• nonanoic acid^[6]
• 3-methylpentanoic acid^[8]
• 4-methylpentanoic acid^[8]

The following are in decreasing order of activity:^[9]

• butyric acid
• methyl eugenol
• methyl salicylate
• (+)-menthol
• eugenyl acetate
• 2,4-dinitrotoluene
• pyrazine
• dimethyl disulfide
• methyl furfuryl disulfide
• pentanol
• propanal

See also

• Olfactory receptor