OR51E2

Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene.^[5][6]

OR51E2
Identifiers
Aliases	OR51E2, OR51E3P, OR52A2, PSGR, olfactory receptor family 51 subfamily E member 2, HPRAJ
External IDs	OMIM: 611268; MGI: 2157548; HomoloGene: 23713; GeneCards: OR51E2; OMA:OR51E2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 4,680,171 bp[1] End 4,697,854 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 102,387,718 bp[2] End 102,408,678 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium popliteal artery tibial arteries prostate muscle layer of sigmoid colon right coronary artery smooth muscle tissue transverse colon rectum left coronary artery Top expressed in umbilical cord carotid body lumbar subsegment of spinal cord muscle of thigh trigeminal ganglion digastric muscle extraocular muscle temporal muscle triceps brachii muscle respiratory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity olfactory receptor activity G protein-coupled receptor activity steroid hormone receptor activity signaling receptor activity Cellular component membrane integral component of membrane plasma membrane early endosome membrane intracellular organelle endosome Biological process sensory perception of smell steroid hormone mediated signaling pathway signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell positive regulation of blood pressure cellular response to fatty acid positive regulation of renin secretion into blood stream G protein-coupled receptor signaling pathway cell migration melanocyte differentiation positive regulation of cAMP-mediated signaling melanocyte proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81285 170639 Ensembl ENSG00000167332 ENSMUSG00000043366 UniProt Q9H255 Q8VBV9 RefSeq (mRNA) NM_030774 NM_001168503 NM_130866 RefSeq (protein) NP_110401 NP_001161975 NP_570936 Location (UCSC) Chr 11: 4.68 – 4.7 Mb Chr 7: 102.39 – 102.41 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[6]

Structure

Structure of the olfactory receptor OR51E2 (green) complexed with miniGs399 and a propionic acid ligand (orange).^[7]

Its structure was determined in 2023, the first elucidation of the structure of a human olfactory receptor.^[7][8][9]

Ligands

OR51E2 is a relatively narrowly tuned olfactory receptor, meaning it responds only to a relatively small set of related odorants.^[10]

OR51E2 responds to short-chain fatty acids,^[11] including in particular propionic acid.^[10]

See also

• Olfactory receptor